Formation of Enamines Investigated in Micro Reactors

3 Formation of Enamines Investigated in Micro Reactors Organic synthesis 73 [OS 73] Stork enamine formation from cyclohexanone and pyrrolidine 

This carbon-carbon bond-generating reaction can be used extensively over a wide range of chemistries [11]. As the reaction is an equilibrium process, needing the removal of water to obtain high yields, chemical means have to be used to accomplish this task. 1,3-Dicyclohexylcarbodiimide (DCC) is a commonly used reagent for this purpose. Alternatively, molecular sieves find use for conventional processing, but are not so favorable for micro-reactor processing, because the sieve needs to be inserted into the micro channel (additional fabrication expenditure) and may disrupt the liquid transport if EOF is applied. 

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