Tumorigenicity formaldehyde

The major ciliastatic components in tobacco smoke are water soluble. These include formaldehyde, acetaldehyde, crotonaldehyde, ethyl carbamate, and hydrazine all are water-soluble tobacco smoke components that appear as tumorigens... 

The U.S. Surgeon General (4010) reported that formaldehyde and acrolein (propenal) were tumorigenic and each was a... 

Hoffmann and Hecht (1727) included formaldehyde, acetaldehyde, and crotonaldehyde (2-butenal) in their list of 43 tumorigenic components of tobacco and tobacco smoke. Their text accompanying the list plus the authors disregard of how the tumorigenicity of many of the 43 components was determined experimentally raises serious questions as to why many of the components were listed. 

OSHA (2825) in its list of 43 tumorigenic components of tobacco smoke included only formaldehyde and acetaldehyde but... 

Hoffmann and Hoffmann (1740, 1741) in their lists of 60 tumorigenic components of tobacco and tobacco smoke included only two aldehydes - formaldehyde and acetaldehyde. Crotonaldehyde (2-butenal) include in the 1990 Hoffmann-Hecht list (1727) was omitted from the Hoffmann-Hoffmann (1740), an omission that paralleled the 1994 OSHA list (2825). 

Tumorigenicity The carcinogenicity of formaldehyde has been under evaluation since the 1970s. Following classification as a known human carcinogen by the International Agency for Research on Cancer in 2006, based on evidence of nasopharyngeal cancer, and in 2009 based on evidence for leukemia, the data have been reviewed and debated. 

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