Big Chemical Encyclopedia

Chemical substances, components, reactions, process design ...

Articles Figures Tables About

Midazolam Foods: Grapefruit juice

Recent concerns with food products include grapefruit juice, which has been shown interact with many different medications through the CYP450 3A4 isoenzyme. This may increase the levels of medication such as cyclosporine, dihydropyridine calcium channel blockers, midazolam, triazolam, and astemizole. ... [Pg.1911]

Especially the inhibition or induction of cytochrome P450 subtype 3A4 (CYP 3A4) is clinically relevant, because a variety of active substances and food substances (e.g. grapefruit juice) are able to affect this enzyme. Substances inhibiting CYP 3A4 include ciclosporin, dihydropyridines, verapamil, midazolam, paclitaxel, simvastatin, lovastatin, atorvastatin, cimetidine, erythromycin, troleandomycin, ketoconazole (and other azoles). Substances inducing CYP 3A4 include steroids, rifampicin, phenobarbital and St John s wort. [Pg.336]


See other pages where Midazolam Foods: Grapefruit juice is mentioned: [Pg.192]    [Pg.192]    [Pg.192]    [Pg.276]    [Pg.279]    [Pg.430]    [Pg.276]    [Pg.279]    [Pg.40]    [Pg.279]   
See also in sourсe #XX -- [ Pg.726 ]




SEARCH



Grapefruit juice

Midazolam

Midazolam grapefruit juice

© 2024 chempedia.info