Food contact notifications specifications

Potential concerns for a constituent of an additive raised by a qualitative SAR analysis may be addressable by a more in-depth, quantitative SAR (QS AR) analysis. The approach to QSAR used in the food contact notification program is to identify the most appropriate specific structural analogs from the pool of chemicals for which adequate carcinogenicity data are available. If, in the expert judgment of FDA reviewers, the analogs can reasonably be considered to be as toxic or more toxic than the compound of concern, these analogs can be used to develop a quantitative estimate of its upper bound LCR. 

US Food and Drug Administration, Centre for Food Safety and Applied Nutrition, Office of Food Additive Safety, August 2002, Inventory of Premarket Notification Limitations, Specifications and use for Food Contact Substances, FCN Nol03, 2002. 

No specific regulatory limits or listings of cadmium compounds, including cadmium pigments, were located in FDA packaging and food contact substances databases at http //www.fda.gov/Food/IngredientsPackagingLabeIing/PackagingPCS/ default.htm (e.g., EAFUS, Inventory of Effective Food Contact Substance Notifications, List of Indirect Additives Used in Food Contact Substances, and Cumulative Estimated Dietary Intake databases). 

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