Fodor

G. Fodor, Acta Univ. Szegediensis Chem. Phys., 21, 167 (1949) Chem Abstr., 44, 6414. 

G. Fodor and G. Wilheim, Acta Chim. Acad. Sci. Hung., 2, 189 (1952) Chem. Abstr.,... 

Recrystd from Me2CO, H2O or Et0H-Et20 and dried. Soluble in H2O (60%) and EtOH (5%) but insol in Et20 and slightly in CHCI3. The hydrochloride has m 300 (from Mc2CO). The free base is a viscous liquid which forms a crystalline hydrate with m 59 and [a] -28° (c 2.7, H2O). Readily hydrolysed in dilute acid or base. [Meinwald J Chem Soc 712 7953 Fodor Tetrahedron 1 86 1957.]... 

MA Gallop, RW Baii et, WJ Dower, SPA Fodor, EM Gordon. Applications of combinatorial technologies to drug discovery. 1. Background and peptide combinatorial libraries. J Med Chem 37 1233-1251, 1994. 

Detailed mechanistic studies by Fodor demonstrated the intermediacy of both imidoyl chlorides (6) and nitrilium salts (7) in Bischler-Napieralski reactions promoted by a variety of reagents such as PCI5, POCI3, and SOCh)/ For example, amide 1 reacts with POCI3 to afford imidoyl chloride 6. Upon heating, intermediate 6 is converted to nitrilium salt 7, which undergoes intramolecular electrophilic aromatic substitution to afford the dihydroisoquinoline 2. Fodor s studies showed that the imidoyl chloride and nitrilium salt intermediates could be generated under mild conditions and characterized spectroscopically. Fodor also found that the cyclization of the imidoyl chlorides is accelerated by the addition of Lewis acids (SnCU, ZnCh), which provides further evidence to support the intermediacy of nitrilium salts. ... 

A. Albert G. Fodor S. Gronowitz J Gut R. Huisgen N. Kochetkov G. Wittig... 

Karrer thought that the dihydro-1,3-oxazine skeleton can possibly be formed in proteins during their transformation to polypeptides. Fodor - and Fiescr explained the stereospecific migration of acyl groups from N to 0 and vice versa in tropine alkaloids by an intermediate formation of a 1,3-oxazine ring. 

Fodor-Csorba K, Dutka F. 1986. Selectivity and sensitivity of some thin-layer chromatographic detection systems. J Chromatogr 365 309-314. 

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