Focus on Regioselectivity and Product Outcome in Organic Synthesis

Peter Nilsson, Kristofer Olofsson and Mats Larhed 

Department of Medicinal Chemistry, Organic Pharmaceutical Chemistry, Uppsala University, 

The Mizoroki-Heck Reaction Edited by Martin Oestreich 2009 John Wiley Sons, Ltd. ISBN 978-0-470-03394-4 

Oxidative addition. The organic snbstrate RX reacts with Pd(0)L2 generating RPd(ll)XL2 (L = monodentate ligand or solvent, X = leaving group), 

n-Complex formation. Either L or X is displaced and paUadium(II) coordinates to the double bond of the alkene, 

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Focus on Regioselectivity and Product Outcome in Organic Synthesis... 

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