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Focal adhesion kinase inhibitor

Yang et al. [13] Hepatocarcinoma Antimetastatic effects apo-8 -lycopenal (1) decreased the activities and protein expression of metalloproteinase-2 (MMP-2) and -9 (2) increased the protein expression of nm23-Hl and the tissue inhibitor of MMP (TIMP)-l and -2 (3) suppressed protein expression of Rho small GTPases and (4) inhibited focal adhesion kinase- nediated signaling pathway, such as ERK 38 and PI3K-Akt axis... [Pg.3882]

Inasmuch as VASP appears to be localized to focal adhesions in intact platelets, the interesting possibility exists that PKG regulates focal adhesion assembly. In a report by Murphy-Ullrich and coworkers (1994), selective inhibitors of PKG, but not PKA or protein kinase C, inhibited thrombospondin-evoked focal adhesion disassembly, suggesting that PKG mediates thrombospondin action. This would be a new role for PKG in regulating cellular shape and motility. The role of VASP in this process is currently unknown, but the availability of cDNA probes for controlling expression of this unique protein may provide answers. [Pg.266]

See other pages where Focal adhesion kinase inhibitor is mentioned: [Pg.223]    [Pg.305]    [Pg.569]    [Pg.56]    [Pg.56]    [Pg.192]    [Pg.307]    [Pg.335]    [Pg.511]    [Pg.187]    [Pg.131]    [Pg.416]    [Pg.33]    [Pg.3893]    [Pg.130]    [Pg.4]    [Pg.64]    [Pg.242]    [Pg.157]    [Pg.183]    [Pg.568]    [Pg.255]   
See also in sourсe #XX -- [ Pg.223 ]



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