Fluoxetine children

Sallee FR, DeVane CL, Ferrell RE. Fluoxetine-related death in a child with cytochrome P-450 2D6 genetic deficiency. 

Suicidality in children and adolescents Antidepressants increased the risk of suicidal thinking and behavior (suicidality) in short-term studies in children and adolescents with major depressive disorder (MDD) and other psychiatric disorders. Anyone considering the use of olanzapine/fluoxetine or any other antidepressant in a child or adolescent must balance this risk with clinical need. 

Birmaher B., Waterman GS, Ryan N, Cully M, Balach L, Ingram J, Brodsky M. Fluoxetine for childhood anxiety disorders. / Am Acad Child Adolesc Psychiatry 33 993-999. 

Black, B. and Uhde, T.W. (1994) Treatment of elective mutism with fluoxetine a double-blind, placebo controlled study. / Am Acad Child Adolesc Psychiatry 33 1000-1006. 

Cook, E.H., Jr., Rowlett, R., Jaselskis, C., and Leventhal, B.L. (1992) Fluoxetine treatment of children and adults with autistic disorder and mental retardation. / Am Acad Child Adolesc Psychiatry 31 739-745. 

Riddle, M.A., King, R.A., Hardin, M.T., and Scahill, L. (1991) Behavioral side effects of fluoxetine in children and adolescents. / Child Adolesc Psychopharmacol 1 ... 

Venkataraman, S., Naylor, M.W., and King, C.A. (1992) Mania associated with fluoxetine treatment in adolescents. / Am Acad Child Adolesc Psychiatry 31 276-281. 

Wegerer, V., Moll, G.H., Bagli, M., Rothenberger, A., Ruther, E., and Huether, G. (1999) Persistently increased density of serotonin transporters in the frontal cortex of rats treated with fluoxetine during early juvenile life. / Child Adolesc Psychopharmacol 9 13-24. 

For most child psychiatrists, the drug interactions most frequently encountered are interactions with other psychotropics. Fluoxetine inhibits the CYP3A isozymes and thus increase the plasma concentration of the tria-zolobenzodiazepines (alprazolam, midazolam, and triazolam), causing increased psychomotor effects (Shader and Greenblatt, 1995). To avoid unwanted psychomotor effects, the dosage of alprazolam should be decreased when it is coadministered with fluoxetine (Chouinard et ah, 1999). Nefazadone has also been shown to increase the pharmacodynamic effects of triazolam and, to a lesser extent, alprazolam (Chouinard et ah, 1999). 

Gammon, G.D. and Brown, T.E. (1993). Fluoxetine and methylphenidate in combination for treatment of attention deficit disorder and comorbid depressive disorder. / Child Adolesc Psychopharmacol 3 1-10. 

Emslie, G.J., Rush, A.J., Weinberg, W.A., Kowatch, R.A., Carmody, T., and Mayes, T.L. (1998) Fluoxetine in child and adolescent depression acute and maintenance treatment. Depress Anxiety 7 32-39. 

Geller, D.A., Hoog, S.L., Heiligenstein, J.H. (2001) Fluoxetine treatment for obsessive-compulsive disorder in children and adolescents a placebo-controlled clinical trial. / Am Acad Child Adolesc Psychiatry 40 773—779. 

Wilens T, Cohen LG, Beiderman J, Abrams A, neft D, Melnick K, Kurtz D, and Sinha V (2000, poster). Pharmacokinetics of fluoxetine in pediatric patients. Scientific Proceedings of the 47th Annual Meeting of The American Academy of Child And Adolescent Psychiatry. October 24-29, 2000). New York, NY. 

Geller, D., Biederman, J., Reed, E., Spencer, T, and Wilens, T. (1995) Similarities in response to fluoxetine in the treatment of children and adolescents with obsessive-compulsive disorder. / Am Acad Child Adolesc Psychiatry 34 36—44. 

Riddle, M., Scahill, L., King, R., Hardin, M., Anderson, G., Ort, S., Smith, J., Leckman, J., and Cohen, D. (1992) Double-blind, ctossovet ttial of fluoxetine and placebo in childten and adolescents with obsessive-compulsive disotdet./ Am Acad Child Adolesc Psychiatry 31 1062-1069. 

Sallee, F.R., DeVane, C.L., and Ferrell, R.E., (2000a) Fluoxetine-related death in a child with cytochrome P-450 2D6 genetic deficiency. / Child Adolesc Psychopharmacol. 10 27-34. 

DeLong, G.R., Teague, L.A., and Kamran, M.M. (1998) Effects of fluoxetine treatment in young children with idiopathic autism. Dev Med Child Neurol 40 551-562. 

Riggs, P., Mikulich, S., Coffman, L., and Crowley, T. (1997) Fluoxetine in drug-dependent delinquents with major depression an open trial. J Child Adolesc Psychopharm 7 87-95. 

Dummit, E.S., 3rd, Klein, R.G., Tancer, N.K., Asche, B., and Martin, J. (1996) Fluoxetine treatment of children with selective mutism an open trial. J Am Acad Child Adolesc Psychiatry 35 615-621. 

Ghaziuddin, M. and Tsai, L. (1991) Fluoxetine in autism with depression./ Am Acad Child Adolesc Psychiatry 30 508—509. 

Avci, A., Diler, R.S., and Tamam, L. (1998) Fluoxetine treatment in 2.5-year-old girl. J Am Acad Child Adolesc Psychiatry 37 901-902. 

Wright, H.H., Cuccaro, M.L., Leonhardt, T.V., Kendall, D.F., and Anderson, J.H. (1995) Case study fluoxetine in the multimodal treatment of a preschool child with selective mutism. / Am Acad Child Adolesc Psychiatry 34 857-862. 

Go FS, Malley EE, Birmaher B, et al. Manic behavior associated with fluoxetine in three 12-18 year olds with OCD. J Child Adolesc Psychopharmacol 1998 8 73-80. 

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