Fluorous Applications in High-Throughput

A fluorous phase Pummerer reaction was introduced by Procter. This report was based on the need to address problems associated with difficulties in optimization and monitoring of solid-phase processes. Good to excellent yields of heterocyclic scaffolds, mainly oxindoles, were reported after the development of a high-throughput fluorous phase synthesis strategy. 

A somewhat different approach was used by Vincent in phase-switching reactions using pyridyl-labelled substrates and products. The pyridyl-containing tag is here thought of as a masked phase tag, which allows for phase switching with the help of a heavy fluorous copper(ll)-carboxylate complex. Comparison with a non-fluorous system indicated that a problem of release of the strongly coordinating pyridine linker was avoided in the fluorous approach.  

A fluorous catch and release method was used by Zhang in the synthesis of di-substituted pyrimidines.A fluorous route to hydantoins and thiohydantoins was also reported by the same group. 

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