Fluoroalkanes and fluoroalkenes

Henry s law constants and octanol-water partition coefficients for fluoroalkanes and fluoroalkenes... 

A. Saito, M. Nakagawa, T. Taguchi, Chromium-mediated fluoroalkenylation reactions of 1,1-dibromo-1-fluoroalkane and 1-bromo-1-fluoroalkene derivatives, J. Fluor. Chem. 126 (2005) 1166-1173. 

A good example of the difficulties involved in accessing toxicological data of organo-fluorine compounds can be seen by examining the work of Hodge, Smith and Chen,5 published in 1963. This included results many of which were mainly preliminary toxicity data, reported in the literature until 1961. Much data that was not comparable in depth of focus, meaningfulness, mode of application, animal material, doses, and quality of research was summarized in this article. Information contained within such an article is difficult for experimental chemists to assess. Further data on the toxicity of fluoroalkanes, fluoroalkenes and fluoropolymers has been published.6... 

The mixtures bromine trifluoride/bromine and iodine pentafluoride/iodine can be successfully employed to prepare bromo- and iodo-substituted fluoroalkanes by addition to poly-fluoroalkenes. The reactions are carried out, in the presence of catalysts aluminum, aluminum/ aluminum triiodide9 or without a catalyst,10 in steel reactors at room temperature or with heating. In most cases the addition products are obtained in high yield (see Table 1). 

Several examples of telomerisation of fluoroalkanes with various telogens are reported in Table 1. All the telogens employed in telomerisation of hydrogenated olefins [21-24] are also efficient for fluoroalkenes and the system of initiator also works well with these telogens. Consequently, a large variety of cleavages of X-Y bonds is possible these bonds can be located at the chain end or in the... 

Unsaturated halogenated compounds with a central C = C or C = C bond undergo cleavage on oxidation in the middle of the molecule and form two carboxylic acids without loss of a carbon atom. The reaction mechanism of the oxidation of internal fluoroalkenes by potassium permanganate includes hydroxylation of the C = C bond in 2 by permanganate, accompanied by dehydrofluorination of the geminal fluoroalkane-1,2-diol 3 and formation of an intermediate fluorocarbonyl compound 4 oxidative cleavage of the C-C bond in 4 leads to the final products 5.1... 

A significant advantage of conducting polymerization and oligomerization of fluoroalkanes in carbon dioxide rather than other solvents is the absence of chain transfer to CO2. Radicals generated from fluoroalkene monomers such as tetrafluoroethylene (TFE) are quite electrophilic, and will undergo facile chain transfer to virtually any hydrocarbon that is present in the system. Moreover, highly reactive monomers such as TFE can be handled more safely as... 

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