Fluoroacetate phenyl

Ethyl fluoroacetate 2-Chloroethyl fluoroacetate 2-Fluoroethyl acetate 2-Fluoroethyl chloroacetate 2-Fluoroethyl fluoroacetate Phenyl fluorothiolacetate 2-Chloroethyl fluorothiolacetate... 

Ethyl fluoroacetate 2>(9iIoroethyI fluoroacetate 2-FluoroethyI acetate 2>FluoroethyI chloroacetate 2 FluoroethyI fluoroacetate Phenyl fluorothiolacetate 2-ChIoroethyI fluorothiolacetate... 

In the phosphorofluoridate series, we found that the diphenyl ester (p. 53) was relatively non-toxic. Phenyl fluoroacetate, however, was toxic with an l.d. 50 of 6-10 mg./kg. for subcutaneous injection into mice. The symptoms were similar to those displayed by methyl fluoroacetate. 

The action of a Grignard reagent, e.g. phenyl magnesium bromide, on methyl fluoroacetate gives among other products PhaCH CH(OH)Ph and desoxybenzoin.1... 

A typical example of such heterocyclization is the interaction of 3-phenyl-5-met-hoxy-l,2,4-triazine 182 with urea or A,A -dimethylurea in acetic or, better, in tri-fluoroacetic anhydride. The role of anhydride consists in converting starting molecule into a more electrophilic triazinium salt 183, which then reacts with a bifunctional nucleophile to form imidazotriazinone 184 (Scheme 54) (00MC58, 01JHC901). 

The reaction of norbornadiene with fluorochlorocarbene (generated from sodium dichloro-fluoroacetate in diglyme at 140 °C) and difluorocarbene [from phenyl(trifluoromethyl)mercury and sodium iodide at 80 °C] gave, in addition to 1,2-addition products, 1,5-addition products 1 and 2 resulting from a linear homocheletropic reaction. ... 

The phenylsulfinyl fluoroacetate can be alkylated with a wide range of alkyl halides and Michael acceptors. Subsequent thermal elimination of phenyl sulfinic acid leads to a-fluoro-a,p-unsaturated ethyl carboxylates, an important class of intermediates for fluorine containing biologically active compounds [19] (Scheme 5.4). 

Ethyl-5-phenyl-2,4,6(lH,3H,5H)- Fluoroacetic acid amide 5351 6-( 3-D-Glucopyranosyloxy)-7- ... 

In 1991, Wright et al. reported a procedure for the preparation of substituted 1-benzyl-1//-1,2,3-triazoles 21 and 23 from benzyl azides 20 under very mild conditions (Scheme 4.7) [9]. Benzyl azides 20 reacted with active methylene compounds in DMSO induced by potassium carbonate at 35-40 C to give 1-benzyl-1//-1,2,3-triazoles 21 and 23 usually in good yield. Acetonitrile derivatives 10 gave 5-amino-l-benzyl-l//-l,2,3-triazoles 21, whereas diethyl malonate gave 5-hydroxy-l-benzyl-l//-l,2,3-triazoles. l//-l,2,3-Triazole-4-carboxylate esters and l//-l,2,3-triazole-4-ketones were obtained from ethyl acetoacetate and P-diketones, respectively. Benzyl methyl ketone reacted to give a 5-methyl-4-phenyl-l//-l,2,3-triazole, but acetone and acetophenone failed to react. Other active methylene compounds that did not react under these reaction conditions included ethyl cyanoacetate, ethyl fluoroacetate, and ethyl nitroacetate. 

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