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Fluorine probe approach study

IV. FLUORINE-CONTAINING TAXOIDS SAR STUDY AND FLUORINE PROBE APPROACH TO THE IDENTIFICATION OF BIOACTIVE CONFORMATIONS... [Pg.91]

We have successfully applied the fluorine probe approach to the estimation of the F-F distance in the microtubule-bound F2-10-Ac-docetaxel (74, SB-T-30021) using the solid-state magic angle spinning (SS MAS) 19F NMR coupled with the radio frequency driven dipolar recoupling (RFDR) technique in our preliminary study.78... [Pg.100]

Ojima, I. Kuduk, S. D. Chakravarty, S. Ourevitch, M. Begue, J. P. A novel approach to the study of solution sturctures and dynamic behavior of paclitaxel and docetaxel using fluorine-containing analogues as probes. J. Am. Chem. Soc., 1997, 119 5519-5527. [Pg.135]

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See also in sourсe #XX -- [ Pg.177 , Pg.179 ]



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