Fluorine-containing ligand introduction

Introduction of Fluorine-Containing Ligands Via Highly Fluorinated Olefins. It is known that [pyCoi(DH)2] will substitute readily the halogen of vinyl and styryl halides (26). On the other hand, [pyCoI(DH)2]- reacts with CH2=CHZ... 

Many bacterial enzymes and proteins, which are modified by the introduction of F-Phe or F-Tryp, have been obtained. Mammalian proteins containing F-Pro or other fluorinated amino acids have also been obtained, either in a direct manner in vivo) or, more efficiently, by the expression of the gene in a bacteria. Thus, trifluoro-methionine has been incorporated by E. coli in the lysozyme of a bacteriophage. Because this enzyme contains three methionines, it has been used to study the interactions of this protein with its ligands by F NMR. ... 

Introduction of Fluoroalkyl Ligands via Fluorinated Aliphatic Alkyl Halides. Organocobaloximes, LCo(DH)2R containing functionalized aliphatic alkyl (R) ligands that do not have a-fluorine (a-F) atom substituents, are prepared in... 

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