Fluorinated ethylene propylene chemical structure

Figure 11.27 Chemical structure of fluorinated ethylene propylene (FEP).

The first dendrimers made were based on PAMAM (Tomalia et al. 1985). It was also the first to be scaled up and commercialized under the name of starburst dendrimers. Poly(propylene imine) (PPI) and poly(ethylene imine) (PEI) are some of the other commonly used dendrimers for drug and gene delivery. Since then, many new dendrimers have been synthesized that possess various properties for specific applications. Incorporation of inorganic molecules into dendrimer structures has shown distinct advantages. For example, the recent carbosilane dendrimers with surface lactose entities seem to possess inherent antiviral properties (Oka et al. 2009). In another case, fluorine molecules were incorporated into the core of dendrimers (Jiang and Yu 2010) that offer potential in fields such as catalysis. Polyester (Padilla De Jesus et al. 2002), polypeptide (Choe et al. 2002), triazine (Lim and Simanek 2008), and poly glycerol (Calderon et al. 2009) are organic dendrimers that have been attached to chemothera-peutics to increase the efficacy of treatment. Many other useful chemical compositions such as the poly (ester acrylate/amide) (PEA) (Swanson et al. 2007) and poly(ether hydroxylamine) (PEHAM) (Tomalia et al. 2006) are commercially available and used in biomedical applications. 

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