9-Fluorenylmethoxycarbonyl amino

C-D Chang, M Waki, M Ahmad, J Meienhofer, EO Lundell, JD Haug. Preparation and properties of N -9-fluorenylmethoxycarbonyl amino acids bearing tert. -butyl side chain protection. Int J Pept Prot Res 15, 59, 1980. 

P Sieber. An improved method for anchoring of 9-fluorenylmethoxycarbonyl-amino acids to 4-alkoxybenzyl alcohol resins. Tetrahedron Lett 28, 6147, 1987. 

GB Fields, RL Noble. Solid phase synthesis utilizing 9-fluorenylmethoxycarbonyl amino acids. Int J Pept Prot Res 35, 161-214, 1990. 

V,7.V,8aS)-3-(AUyloxycarbonylmethyl)-7-[(9-fluorenylmethoxycarbonyl)amino]-l,4-dioxooctahy-dr pyrr lo[l,2-a]pyrazhie-8a-acetic Acid 11421... 

Wang and Porter [92] resolved the enantiomers of oxazepam, lorazepam, and temazepam using /1-cyclodextrin as the CMPA by CEC. The authors varied separation parameters such as voltage and mobile phase. Wei et al. [93] resolved the enantiomers of phenylephrine and synephrine by varying the concentration of /1-cyclodextrin (CMPA), pH, electrolyte concentration, and temperature. Lelievre et al. [99] separated the enantiomers of chlorthalidone using hydroxypropyl /1-cyclodextrin as the CMPA. Lammerhofer and Lindner [90] resolved the enantiomers of N-derivatized amino acids (e.g., 3,5-dinitrobenzoyl, 3,5-dinitro-benzyloxycarbonyl, 2,4-dinitrophenyl, and 9-fluorenylmethoxycarbonyl amino... 

Peptide Synthesis with iV -9-Fluorenylmethoxycarbonyl Amino Acid... 

Acylation with A"-9-Fluorenylmethoxycarbonyl Amino Acid Fluorides... 

Figure 1 Coupling of A -9-Fluorenylmethoxycarbonyl Amino Acid Fluorides with H-(Me)Aib-OMel l ( Phe, T Ala, Val)P8]...

Carpino LA, Han GY. The 9-fluorenylmethoxycarbonyl amino-protecting group. J Org Chem 1972 37 3404-3409. 

Lepri et al. investigated the chromatographic behavior of racemic dinitropyridyl, dinitrophenyl, dinitrobenzoyl, 9-fluorenylmethoxycarbonyl amino acids, tryptophanamides, lactic acid derivatives, and unusual enantiomers such as binaphthols on reversed phase TLC plates developed with aqueous-organic mobile phase containing bovine serum albumin (BSA) as chiral agent. More than 75 racemates has been separated in these experiments with planar chromatography using BSA in mobile phase. BSA showed enantioselectivity towards racemates with structures completely different from amino acids, their derivatives, and similar compounds such as hydroxy acids. 

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