Fluid leakage, tumors

Finally, changes in the brain that occur during the course of therapy are not properly considered in this model. Irradiation can be safely administered when a BCNU-loaded polymer has been implanted in monkey brains, suggesting the feasibility of adjuvant radiotherapy. Flowever, irradiation also causes necrosis in the brain. The necrotic region has a lower perfusion rate and interstitial pressure than tumor tissue thus, the convective interstitial flow due to fluid leakage is expected to be smaller. Interstitial... 

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