Flow Reactions with an Immobilized Stoichiometric Reagent

Flow Reactions with an Immobilized Stoichiometric Reagent 

When the Jones oxidation of benzyl alcohol was carried out in a batch reactor, formation of a mixture of the starting material, benzaldehyde, and benzoic acid was observed. In contrast, the flow conditions using a gravity fed-type packed-bed reactor filled with the silica-supported Jones reagent revealed very unique results. While 

The method allows easy handling of large quantities of insoluble CsF with precise control [42]. 

The catch and release monolithic phosphine can be employed in a flow Appel reaction [53]. The monolith (9) was treated with carbon tetrabromide to give the active bromophosphonium (10), with which alcohols were transformed into alkyl bromides. As a result, the functional group on the monolith changed into phosphine oxide. Although complete bromination of reactive benzyl alcohols 

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Flow Reactions with an Immobilized Stoichiometric Reagent 161... 

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