Fletcher and Robinson

Micelles are thermodynamically stable at the same time they are highly dynamic systems, as they break and re-form rapidly, and exchange material by continuous collisions and fusion processes (Fletcher and Robinson, 1981 Harada and Schelly, 1982). Figure 9.10 gives an illustration of this for reverse micelles, but aqueous micelles are similarly highly dynamic (Ulbricht and Hoffmann, 1993). 

Figure 9.10 Some structural details and dynamic properties of reverse micelles 50 irtM AOT/isooctane, Wo = 11.1 (= 10 p lHoOperml), 25°C 3.2% AOT (w/w), 1.4% H2O (w/w) mean water pool radius 20 A, mean hydrohynamic radius 32 A concentration of micelles 400 (xM, monomer AOT concentration 0.6-0.9 mM aggregation number 125 total interfacial area 14 m mC (Adapted from Fletcher and Robinson, 1981, and Harada and Schelly, 1982.)...

Fletcher and Robinson [58] pointed out that the kinetic scheme was basically no different for w/o microemulsions than for regular micellar solution. They investigated kinetically the Ni /PADA complexation reaction in the sodium bis-(2-ethylhexyl)sulfo-succinate (AOT)/ -heptane system where a 10-fold rate enhancement was observed with no change in the rate coefficients. The AOT system is frequently the microemulsion of choice for w/o systems because its properties have been well characterized for different ratios of water to oil. 

To summarize the preceding features we can conclude, as did Fletcher and Robinson,i i that (1) for reactions on the nanosecond time scale droplets can be considered isolated and... 

According to Fletcher and Robinson [81], when pp is much greater than [Sjjpp, Equation 15.2 can be expressed as... 

Winston A, Back D, Fletcher C, Robinson L, Unsworth J, Tolowinska I, Schutz M, Pozniak AL, Gazzard B, Boffito M. Effect of omeprazole on the pharmacokinetics of saquinavir-500 mg formulation with ritonavir in healthy male and female volunteers. AIDS (2006) 20, 1401-6. 

Laurie Peter, Derek Fletcher, Jim Robinson and David Schiffrin. His work in Newcastle and Southampton led to numerous contributions in ... 

The seminal paper in this held came from Fletcher, Howe, and Robinson [107], who emphasized that droplet exchange (via coalescence/hssion) is rapid and continuous. They were even able to determine the activation barrier to water exchange for AOT-stabilized water-in-oil microemulsions (on the order of 70-100 UmoF ). with an associated rate constant for water exchange of 10 -10 moF dm S". ... 

R. Greef, R. Peat L. M. Peter, D. Fletcher and J. Robinson (1985) Instrumental Methods in Electrochemistry, Ellis Horwood, Chichester. 

Alburn, H.E., Grant, N.H. and Fletcher, H. Ill US Patent 3,194,802 assigned to American Home Products Corporation Robinson, C.A. and Nescio, J.J. US Patent 3,478,018 November 11, 1969 assigned to American Home Products Corporation... 

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