Fleroxacin Theophylline

Noninterfering adenosine, albuterol, alphenal, aspirin, caffeine, carbamazepine, cefazo-lin, cephalexin, cephalothin, cimetidine, ciprofloxacin, claforan, desipramine, enoxacin, fleroxacin, furosemide, hydralazine, hydrochlorothiazide, minoxidil, norfloxacin, pheny-toin, propafenone, sulindac, teicoplanin, theophylline, vancomycin Interfering some indocyanine green impurities... 

Theophylline serum levels can be markedly increased in most patients by enoxacin. Pipemidic acid and clinafloxacin probably interact similarly. Theophylline levels can also be markedly increased in some patients by ciprofloxacin, and possibly pe-floxacin. Norfloxacin, ofloxacin, pazufloxacin, or prulifloxacin normally cause a much smaller rise in theophylline levels. However, serious toxicity has been seen in few patients given norfloxacin. Fleroxacin, flumequine, gatifloxacin, gemifloxacin, levofloxacin, lomefloxacin, moxifloxacin, nalidixic acid, rufloxacin, spar-floxacin and trovafloxacin appear not to interact. 

Niki Y, Tasaka Y, Kishimoto T, Nakajima M, Tsukiyama K, Nakagawa Y, Umeki S, Hino J, Okimoto N, Yagi S, Kawane H, Soejima R Effect of fleroxacin on serum concentration of theophylline. Chemotherapy (1990) 38, 364-71. 

Seelmann R, Mahr G, Gottschalk B, Stephan U, Sorgel F. Influence of fleroxacin on the pharmacokinetics of theophylline. Rev Infect Dls (1989) 11 (Suppl 5), SHOO. 

Parent M, St-Laurent M, LeBel M. Safety of fleroxacin coadministered with theophylline to young and elderly volunteers. Antimicrob Agents Chemother (1990) 34,1249-53. 

Noninterfering amikacin, aztreonam, carbamazepine, cephalosporins, ciprofloxacin, clavulanic acid, difloxacin, digitoxin, digoxin, fleroxacin, fosfomycin, furosemide, gentamicin, imipenem, lidocaine, netilmicin, norfloxacin, ofloxacin, pefloxacin, penicillins, phenobarbital, phenytoin, primidone, procainamide, quinidine, rifampin, salicylic acid, teicoplanin, theophylline, tobramycin, valproic acid, vancomycin... 

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