Flavothebaone trimethyl ether

The Beckmann transformation of flavothebaone trimethyl ether oxime yields an isoxime containing four methoxyl groups, which on treatment with methanol and hydrochloric acid yields a substance yrith one additional methoxyl. Both the isoxime and the methyl-derivative remain unchanged on heating with methanolic potassium hydroxide for seven hours [2],... 

On the basis of the structure [xlv] flavothebaone trimethyl ether mothino is soon to be [xlvii,] and the nitrogen-free substonoo C2oHM05 obtainod from the Hofmann degradation to bo [xlviii]. The natures of... 

The Beckmann rearrangement of flavothebaone trimethyl ether oxime [xlix] could lead to the amide [l], which could give the corresponding amino methyl ester on heating with methanolic hydrogen chloride. 

Reticuline (129) has been converted into the cepharamine-type compound (130) using a phenol oxidative coupling reaction as the key step. The Hofmann degradation of flavothebaone trimethyl ether t/ -methine (131) has been reexamined and shown to give (133) as the major product, presumably formed via... 

No crystalline product is obtained when flavothebaone is oxidized with hydrogen peroxide, ozone, or other reagents. The trimethyl ether can be converted to a N-oxide on oxidation with perbenzoic acid the N-oxide is reduced to the parent base by sulphurous acid. The trimethyl ether can be brominated to a dibromo-derivative [2],... 

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