Fixed break point, estimation

In the downstream processing of bioprocesses, fixed-bed adsorbers are used extensively both for the recovery of a target and for the removal of contaminants. Moreover, their performance can be estimated from the breakthrough curve, as stated in Chapter 11. The break time tg is given by Equation 11.13, and the extent of the adsorption capacity of the fixed bed utilized at the break point and loss of adsorbate can be calculated from the break time and the adsorption equilibrium. Affinity chromatography, as weii as some ion-exchange chromatography, are operated as specific adsorption and desorption steps, and the overall performance is affected by the column capacity available at the break point and the total operation time. 

Design a 250,000 Ib/yr Lindane (99 per cent 7 isomer of benzene hexachloride) plant based on process information given in the current literature [e.g., see Chem. Eng. Progr., 52 281 (1956) Chem, Week, 78 54 (1956) Ind. Eng. CAem., 48(10) 41A (1956)], Develop the process flow. sheets, equipment specifications, and plant layout. Examine the economics of producing Lindane including (1) fixed and capital cost estimates by one or more of the methods outlined in Chap. 6, (2) profitability analysis showing return on investment and pay-out time, (3) break-even point analysis of the project, (4) economic estimates for a plant producing 500,000 Ib/yr and 750,000 Ib/yr. 

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