Fish proteins factors influencing

The circulatory system of fish is also unique structurally and functionally. Structurally, the membranous nature of the vasculature makes for a friable high-capacitance system under low pressure. Low blood flows result in somewhat longer distributional phases for many drugs. Processes such as heart rate and stroke volume that influence drug distribution are themselves influenced by external factors such as temperature and stress. In addition, total plasma protein content differs in fish as compared to mammals. Total plasma protein in the trout and flounder is approximately one-half that of mammals such as dogs and cats. For many compounds protein binding is considerably lower in fish than their mammalian counterparts (19, 20). 

The composition of fish striated muscle with respect to water, proteins, and lipids differs widely from one species to another, and within a species seasonal variations may occur. The influence of this factor has been investigated by Van Wyk (1944). In fatty fishes, an important increase in fat content is observed in Spring or in Summer, with a corresponding decrease in water content, while the nitrogen values remain relatively constant. Determinations made on many species by various authors have been compiled by Jacquot and Creac h (1950). Other evaluations have been done more recently on numerous Spanish fishes (De Las Heras and Mendez Isla, 1952) on a few Kolhapur fresh-water fishes (Airan and Joshi, 1952), and on Skipper Cololabis saira) (Tsuchiya et ah, 1953). Some of the figures given by Jacquot and Creac h (1950) are reproduced in Table I, which contains for each species a mean value or sometimes two values corresponding to the limits of variation. Water accounts for three-... 

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