Fisetin structure

The degree of inhibition is dependent on the type of inducer and on the structure of the flavonoid. At 30 pM, fisetin, kaempferol or quercetin inhibit the platelet aggregation induced by arachidonic acid, whereas morin and myricetin are effective only at concentrations greater than 150 pM... 

The gamma-chromene structure appears in many natural products as derivatives with a 4-keto group. The parent is known as chromone (3.56), and it is found especially in the flavone (flavonoid) family, which has a 2-phenyl substituent. Flavone itself has structure 3.57 and is a yellow solid found in plants. A flavonoid from strawberries, fisetin (3.58), is said to have weak memory-enhancing ability. ... 

In efforts to apply the reaction to total synthesis, Nierenstein reported the synthesis of fisetol 15, a product of disintegration of the flavonol fisetin. It was reported during his studies on the action of diazomethane on aromatic acyl chlorides. Some other flavonols are quercetin, datiscetin, myricetin, quercetagetin, and gosspyetin. The synthesized molecule was observed to show the same properties as that prepared by Sonn and Falkenheim by a different method, thus confirming its structure. 

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