Fischer, Edmond

Filamin 370 Filaria worms 24 Fimbriae 6. See also Pili Fingerprinting. See also Peptide mapping of DNA 259 of proteins 118, 360 First Law of Thermodynamics 282 First order reactions 457 Fischer, Edmond H. 84 Fischer, Emil H. 42, 83 Fischer projection formula 42 of monosaccharides 163 FK506 488 Flagella... 

The general idea of this mechanism was promptly confirmed both for the decarboxylation of acetoacetate, and for the physiologically much more important reaction of transaldolase. In both cases, the development depended upon a new tool introduced in 1958 by Edmond Fischer and... 

Edmond H. Fischer and Edwin G. Krebs Physiology/Medicine Reversible protein phosphorylation in biological regulation... 

The control of glycogen phosphorylase by the phosphorylation-dephosphorylation cycle was discovered in 1955 by Edmond Fischer and Edwin Krebs50 and was at first regarded as peculiar to glycogen breakdown. However, it is now abundantly clear that similar reactions control most aspects of metabolism.51 Phosphorylation of proteins is involved in control of carbohydrate, lipid, and amino acid metabolism in control of muscular contraction, regulation of photosynthesis in plants,52 transcription of genes,51 protein syntheses,53 and cell division and in mediating most effects of hormones. 

Reversible chemical modification of enzymes, which was discovered in 1955 by Edmond Fischer and Edwin Krebs [58], is a more prevalent mechanism for cellular signaling switching. Fischer and Krebs showed that enzymes can be turned from an inactive form to an active form via phosphorylation of certain residues of the protein. Enzymes that catalyze phosphorylation (addition of a phosphate group coupled with ATP or GTP hydrolysis) are called protein kinases. Enzymes that catalyze dephosphorylation (which is not the reverse reaction of the phosphorylation) are called phosphatases. For example, a protein tyrosine phosphatase is an enzyme that catalyzes the removal of a phosphate group from a tyrosine residue in a phosphorylated protein [57],... 

Cyclic AMP (= cAMP) (cyclic nucleotide) Earl Sutherland (USA, Nobel Prize, Medicine, 1971, cAMP as second messenger) Edwin Krebs Edmond Fischer (USA, Nobel Prize, Medicine, 1992, PKA)... 

Edwin Krebs Edmond Fischer (USA, Nobel Prize, Medicine,... 

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