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Final Considerations on the Chemoreceptor Complex

The evidence presented above indicates that the presence of glomus cells is a requisite for hypoxic chemoreception. However, some limitations in the interpretation of the above considerations must be presented here  [Pg.359]

That glomus cells exhibit membrane and cytoplasmic changes in response to hypoxia is very well documented (see Refs. 52-54), but the only way to demonstrate that hypoxia-induced glomus cell excitation initiates the full chemoreceptor process is by recording sensory discharges from the adjacent nerve fibers. [Pg.359]

Local destruction of glomus cells is commonly accompanied by elimination—or at least dedifferentiation—of sustentacular cells, whose actions have seldom been searched for and whose importance is poorly understood. [Pg.359]

Elimination of glomus cells suppresses not only their transduction mechanisms for natural chemical stimulation but also their possible trophic effects upon adjacent sensory nerve endings. [Pg.359]

Destruction of the parenchymal cells of the carotid body (both glomus and sustentacular cells)—by either cryocoagulation or by hgature-induced ischemia— is accompanied by a profound distortion of the rich vascularization of the carotid body, whose consequences may contribute to the abohtion of the hypoxic chemoreception observed. [Pg.359]


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