Fibrinolysis drugs

The Pharmaceutical Industiy. Pepsin, trypsin and chymotrypsin have been used clinically as a digestive aid, especially when coated to protect against damage in the stomach, and also in the preparation of precooked cereals and baby foods. Proteases have also been used medically for fibrinolysis, as anti-inflammatory agents in the potentiation of drug activity, and in the treatment of cystic fibrosis, burns, ulcers and acne. 

Regulation of the fibrinolytic system is useful in therapeutics. Increased fibrinolysis is effective therapy for thrombotic disease. Tissue plasminogen activator, urokinase, and streptokinase all activate the fibrinolytic system (Figure 34-3). Conversely, decreased fibrinolysis protects clots from lysis and reduces the bleeding of hemostatic failure. Aminocaproic acid is a clinically useful inhibitor of fibrinolysis. Heparin and the oral anticoagulant drugs do not affect the fibrinolytic mechanism. 

Extrapolation of toxicological and pharmacological data from animals to humans, 20, 1 Factors affecting the storage of drugs and other xenobiotics in adipose tissue, 25, 55 Fibrinolysis, 7,107... 

Krysiak, R., Okopien, B., and Herman, Z. (2003). Effects of HMG-CoA reductase inhibitors on coagulation and fibrinolysis processes. Drugs 63 1821-1854. 

Fibrinolytic system the mode of action of drugs that promote fibrinolysis (fibrinolytics) and their uses to lyse arterial and venous thrombi (thrombolysis)... 

Some adverse effects are associated with all antifibrinolytic agents, reflecting their effect on clot stability. Dissolution of extravascular blood clots may be resistant to physiological fibrinolysis. These drugs should not to be used to treat hematuria due to blood loss from the upper urinary tract, as this can provoke painful clot retention and even renal insufficiency associated with bilateral ureteric obstruction (25-31). 

Drugs affecting blood coagulation, fibrinolysis, and hemostasis... 

Enzyme inhibition is one of the ways in which enzyme activity is regulated experimentally or naturally. Most therapeutic drugs function by inhibition of a specific enzyme. Inhibitor studies have contributed much of the available information about enzyme kinetics and mechanisms. In the body, some of the processes controlled by enzyme inhibition are blood coagulation (hemostasis), blood clot dissolution (fibrinolysis), complement activation, connective tissue turnover, and inflammatory reactions. 

---