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Fibrinogen vitronectin

A Vitronectin Von Willebrand factor Fibrinogen Fibronectin Adhesion... [Pg.135]

CD41/61 representing the GPIIb-IIIa complex, which is a receptor for fibrinogen, von Willebrand factor, fibronectin, and vitronectin. This complex is essential for platelet aggregation. [Pg.156]

Cooper et al. [21, 22] reported in detail the results of their laborious work on the adsorption of four proteins human serum albumin (HSA), fibrinogen (FGN), fibronectin (FN), and vitronectin (VN), on five biomaterials polyethylene (PE), silicone rubber (SR), Teflon-FEP (FEP), poly(tetramethylene oxide)-poly-urethane (PTMO-PU), and polyethylene oxide)-polyurethane(PEO-PU). Hard segments of these polyurethanes are composed of a methylene-bis(p-phenylisocyanate) (MDI) chain extended wih 1,4-butanediol. [Pg.13]

The presence of the tripeptide RGD sequence, and its crucial role in the cell-attachment process, were found subsequently in vitronectin [32, 133], fibrinogen [134], von Willebrand factor [134], type I collagen [135], and many other proteins present in body fluids and extracellular matrices [136],... [Pg.36]

Cheresh DA, Spiro RC. Biosynthetic and functional properties of an Arg-Gly-Asp directed receptor involved in human melanoma cell attachment to vitronectin, fibrinogen, and von Willebrand factor. J Biol Chem 1987 262(36) 17,703-17,71 I. [Pg.24]

Fabriziushoman DJ, Cooper SL (1991) Competitive adsorption of vitronectin with albumin, fibrinogen, and fibronectin on polymeric biomaterials. J Biomed Mater Res 25(8) 953-971... [Pg.74]

Fig. 3.8 Despite their common scaffold, compound 33 is a selective fibrinogen (GPIIb/llla) receptor ligand, whereas 34 is a selective vitronectin (a,fl3) receptor ligand their selectiv-ities differ by more than seven orders of magnitude. Fig. 3.8 Despite their common scaffold, compound 33 is a selective fibrinogen (GPIIb/llla) receptor ligand, whereas 34 is a selective vitronectin (a,fl3) receptor ligand their selectiv-ities differ by more than seven orders of magnitude.
Figure 2.16 Like the 5-HT receptor ligands 53 and 54 (Figure 2.15), also lotrafiban 56 (failed in phase III clinical trials) and compound 57 differ only in their amine component but are highly selective for different integrins. Lotrafiban binds preferentially to the fibrinogen receptor (integrin GP b/ma), with a selectivity factor of about 4000, whereas 57 binds preferentially to the vitronectin receptor (integrin aj ), with a selectivity factor of 15 000. Overall, this constitutes a selectivity ratio of more than seven orders of magnitude. Figure 2.16 Like the 5-HT receptor ligands 53 and 54 (Figure 2.15), also lotrafiban 56 (failed in phase III clinical trials) and compound 57 differ only in their amine component but are highly selective for different integrins. Lotrafiban binds preferentially to the fibrinogen receptor (integrin GP b/ma), with a selectivity factor of about 4000, whereas 57 binds preferentially to the vitronectin receptor (integrin aj ), with a selectivity factor of 15 000. Overall, this constitutes a selectivity ratio of more than seven orders of magnitude.
See other pages where Fibrinogen vitronectin is mentioned: [Pg.144]    [Pg.571]    [Pg.1884]    [Pg.81]    [Pg.118]    [Pg.248]    [Pg.47]    [Pg.144]    [Pg.163]    [Pg.47]    [Pg.557]    [Pg.132]    [Pg.144]    [Pg.571]    [Pg.1884]    [Pg.81]    [Pg.118]    [Pg.248]    [Pg.47]    [Pg.144]    [Pg.163]    [Pg.47]    [Pg.557]    [Pg.132]    [Pg.377]    [Pg.637]    [Pg.137]    [Pg.135]    [Pg.135]    [Pg.105]    [Pg.21]    [Pg.236]    [Pg.237]    [Pg.175]    [Pg.36]    [Pg.767]    [Pg.767]    [Pg.409]    [Pg.776]    [Pg.14]    [Pg.5]    [Pg.32]    [Pg.32]    [Pg.33]    [Pg.187]    [Pg.146]    [Pg.193]    [Pg.195]    [Pg.61]    [Pg.52]    [Pg.377]    [Pg.637]    [Pg.13]    [Pg.166]    [Pg.209]   
See also in sourсe #XX -- [ Pg.178 , Pg.189 ]



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