Fibrinogen physical properties

Physical Properties of Serum Albumin, Fibrinogen, and Tobacco Mosaic Virus... 

Physical property Serum albumin Fibrinogen Tobacco mosaic virus ... 

The poly (HEM A) sheets were prepared by B. Ratner using a special technique he developed. The HEMA solutions were poured between glass plates, and polymerization was chemically initiated. The chemical and physical properties of this material are very similar to those of radiation-grafted poly (HEMA) insofar as protein adsorption is concerned. Heterogeneous or homogeneous poly (HEMA) films were made by polymerization in solvents in which the poly (HEMA) is insoluble or soluble, respectively the result is a white opaque material in the first case and a transparent material in the second case. The resulting films were washed free of excess monomer and then soaked in the buffer to be used in the fibrinogen adsorption experiment for 10 days at 37 °C prior to the actual experiment. 

Ferry, J. D., and Morrison, P. R. (1945). The Physical Properties of Fibrin Films Prepared from Human Fibrinogen and Thrombin. II. Interim report under Contract OEMcmr-139 with the Committee on Medical Research and Development. 

Studies of plasma clots made under a variety of conditions suggest that the network is established early as a result of the activation process (Blomback et al., 1994) and that the thrombin activation pathway modulates clot structure (Torbet, 1995). Light scattering studies, combined with other physical chemical techniques, have substantiated this conclusion for purified fibrinogen and provided more information about the structure and properties of the assembling clot (Bernocco et al., 2000 Ferri et al., 2001, 2002 Profumo et al., 2003). 

Crosslinked poly(amido-amines) are by themselves inert towards the coagulation parameters of blood. We have demonstrated that they do not affect recalcification time, prothrombin time, thrombin time, or fibrinogen content of unheparinized blood, at any speed of filtration from 2 to 200 ml/min. Their biological effects and physical and chemical properties lead us to visualize their being used to make molecular filters capable of de-heparinizing blood. Application of the filters in clinical apparatus can be envisaged (21-23). 

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