Fibrin foam, human

Bering, E.A. (1944) C4iemical, clinical and immunological studies on tire products of human plasma fractionation. XX. The development of fibrin foam as a hemostatic agent and for use in conjunction tvith human thrombin./ Clin. Iinvsl.. 23, 586-589. 

This is a dry sponge of human fibrin prepared by elotting a foam of human fibrinogen solution with human thrombin. It is then freeze-dried, cut into shapes and sterilized by dry heat at 130°C for 3 hours. Before use, it is saturated with thrombin solution. Blood coagulation occurs in contact with the thrombin in the interstices of the foam. 

We have recently presented ascorbate deficiency as the primary cause of human CVD. We proposed that the most frequent pathome-chanism leading to the development of atherosclerotic plaques is the deposition of Lp(a) and fibrinogen/fibrin in the ascorbate-deficient vascular wall. - In the course of this work we discovered that virtually every patho-mechanism for human CVD known today can be induced by ascorbate deficiency. Beside the deposition of Lp(a) this includes such seemingly unrelated processes as foam cell formation and decreased reverse-cholesterol... 

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