Fibrillar aggregation

Figure 5.125 Structure of collagen fibers based on collagen molecule, microfibrils and fibrillar aggregation. Reprinted, by permission, from I. V. Yannas, in Biomaterials Science, B. D. Ratner, A. S. Hoffman, F. J. Schoen, and J. E. Lemons, eds., p. 86. Copyright 1996 by Academic Press.

In summary, stable fibrillar aggregates were obtained from all macro monomers A-E, which had end groups capable of N—H 0=C type hydrogen bonding. 

The amyloidoses are a class of conformational diseases that arise from the conversion of normally unfolded or globular proteins into fibrillar aggregates that are either pathogenic or non-functional. At present there are more than 20 proteins that are associated with human amyloid diseases. This review focuses on three natively unfolded proteins that form fibrillar aggregates amyloid-, islet amyloid polypeptide ( amylin ), and a-synuclein, the diseases they contribute to and chemical and biophysical approaches that are used to investigate these proteins aggregation. 

Solomon B, Koppel R, Hanan E, Katzav T (1996) Monoclonal antibodies inhibit in vitro fibrillar aggregation of the Alzheimer beta-amyloid peptide. Proc Natl Acad Sci USA 93 452-455. 

In both the schemes, the intermediates lead to the formation of amorphous and fibrillar aggregates that causes light chain deposition disease and light chain... 

Another property of fibronectin is its ability to assemble at nucleation sites on the cell surface into disulfide cross-linked fibrillar aggregates independently of interactions... 

An idealised structure (Figure 11.120) shows that they must have an anisotropic (bipolar) structure, which explains a strong tendency to form aggregates, especially linearly arranged, fibrillar aggregates to screen the charges. 

Figure 3. Polarized Raman spectra from a fibrillar aggregate of VaIonia cellulose. The angle between the electric vector and the chain axis was varied from 0° to 90°.

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