Fexofenadine Ethanol

Ten 250 ml Erlenmeyer flasks containing 100 ml of medium D are seeded with A. corymbifera LCP 63-1800. 50 mg of Terfenadine in 1 ml of ethanol is added to each Erlenmeyer flask. The content of 10 Erlenmeyer flasks are filtered on gauze (the supernatant has a pH equal to 8.0), and saturation with sodium chloride is carried out for 2 hours (pH = 5-6), followed by extracting 3 times with ethyl acetate and drying over magnesium sulfate. After evaporation under reduced pressure, 409 mg of expected crude product is obtained (yield = 77%, approximately 90% pure product). This product is purified on a column of silica gel (230-400 mesh, 40 g of silica, diameter = 3 cm) eluting with a methylene chloride/methanol/ammonium hydroxide mixture (82.5 15 2.5). 312 mg of pure Fexofenadine is recovered (61.4%). 

Fexofenadine Hydrochloride. Fexofenadine hydrochloride. ( )-4-( I -hydroxy-4-(4-(hydroxydiphenylmelhjlh l-piperinyl]butyl-a,cr-dimethylbenzeneacctic acid I.AIk-gra), occurs as a white to off-white crystalline powder ilui is freely soluble in methanol and ethanol, slightly soluble in chloroform and water, and insoluble in hexane. This compound is marketed as a racemate and exi.sts as a zwitlerion in aqueous media at physiological pH. 

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