Feverfew administration

BACKGROUND ASPECTS History of the medicinal use of feverfew Today s claims and uses Administration of the herb feverfew... 

Today, as in the Middle Ages, there are different ways in which feverfew is employed with respect to the part of the plant consumed, the frequency and the dose of administration. The vast majority of users appear to consume the leaves [2, p. 46], which are said to taste quite bitter. Commercial feverfew preparations are widely available in the U.K. and many other countries. They contain either dry powdered leaves or whole plant in tablet or capsule form. 

In a study designed to evaluate the pharmacokinetics and toxicity of parthenolide, the active component of feverfew, doses of 1, 2, 3, and 4 mg were studied in a dose escalation fashion (22). Administration of feverfew in escalating doses up to 4 mg showed no toxicity and a maximum tolerated dose was not reached. Despite a parthenolide detection level of 0.5ng/mL, no measurable concentrations of this component could be measured at any of the administered doses levels. 

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