Fever, treatment, cyclooxygenase

Celecoxib is a selective COX-2 inhibitor/GI agent that reduces inflammation (e.g., pain, redness, swelling, heat), fever, and pain by inhibiting chemicals in the body that cause inflammation, fever, and pain. This is probably caused by the inhibition of prostaglandin synthesis, primarily via inhibition of cyclooxygenase-2 (COX-2) isoenzyme. Celecoxib is indicated in relief of symptoms of osteoarthritis relief of symptoms of rheumatoid arthritis in adults management of acute pain in adults treatment of primary dysmenorrhea and reduction of the number of adenomatous colorectal polyps in familial adenomatous polyposis (FAP), as an adjunct to usual care (e.g., endoscopic surveillance, surgery). 

Diclofenac decreases inflammation, pain, and fever, probably through inhibition of cyclooxygenase activity and prostaglandin synthesis. It is indicated in the treatment of rheumatoid arthritis, ankylosing spondylitis, and osteoarthritis. Potassium salt is approved for management of mild to moderate pain and primary dysmenorrhea when prompt pain relief is needed. Ophthalmic used for treatment of postoperative inflammation after cataract removal temporary relief of pain and photophobia following corneal refractive surgery. Topical used for treatment of actinic keratosis. 

Valdecoxib is a nonsteroidal antiinflammatory drug (NSAID) that inhibits inflammation, pain, and fever, probably by inhibition of cyclooxygenase-2 (COX-2). It is indicated in the relief of signs and symptoms of osteoarthritis and adult rheumatoid arthritis and treatment of primary dysmenorrhea. 

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