Fetus health assessment

High levels of pregnancy complications in women exposed to harmful chemical substances testify to early formation of infringements in system mother - placenta - fetus and, in particular, infringement of its permeability. The index of permeability of placenta (IPP) that enables to assess barrier functions of placenta has been calculated, to predict the possible long term risks for newborn health based on the knowledge of specific character of chemical substance. 

EPA also allows for the use of subchronic and developmental RfDs in specific cases where exposures are less than chronic. Subchronic RfDs are to be used for characterizing potential noncarcinogenic effects associated with shortterm exposures lasting from 2 wk to 7 yr (USEPA 1989). Developmental RfDs are used to evaluate the potential effects on the developing fetus following a single exposure event. Subchronic RfDs accepted for use in the preparation of Superfund risk assessments are available in EPA s Health Effects Assessment Summary Table (HEAST USEPA 1996a). 

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