Fetal warfarin syndrome

Treatment of pregnant women with warfarin can lead to fetal bone abnormalities (fetal warfarin syndrome). Two proteins are present in bone that contain y-carboxygluta-mate, osteocalcin and bone matrix Gla protein. Osteocalcin also contains hydroxyproHne, so its synthesis is dependent on both vitamins K and C in addition, its synthesis is induced by vitamin D. The release into the circulation of osteocalcin provides an index of vitamin D stams. 

The fetal warfarin syndrome involves neurological as well as bone abnormalities. Vitamin K-dependent carboxylase is expressed in different brain regions at different times during embryological development. 

Pregnancy in early pregnancy the fetal warfarin syndrome is a hazard and bleeding may cause fetal death in late pregnancy... 

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