Vaccinia fetal

Less than 50 cases of fetal vaccinia have occurred, usually following primary vaccination of the mother in early pregnancy. Fetal vaccinia generally causes a stillbirth or neonatal death. The vaccine is not associated with congenital anomalies. No cases occurred among the 39,213 civilians receiving vaccination in 2003 (15). 

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During the US pre-event smallpox vaccination program, there were no reports of eczema vaccinatum, progressive Vaccinia, or fetal Vaccinia (19,20). 

Includes patients with lesions that had bacterial superinfection, or that made the patient uncomfortable enough to consult a physician. Unusual complications included were a patient with fetal vaccinia, a patient with a melanoma developing in the vaccine scar, and a patient with monoarticular arthritis following vaccination. 

Pregnancy. There have been rare instances of fetal vaccinia, usually following primary vaccination of pregnant women.102 103 This complication usually resulted in fetal demise or early postnatal mortality. 

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