Ferrocenyl redox products

In the open series, of which 14 and 15 are the most studied representatives, a number of distinctive traits can be seen. It has been possible to change the paradigm, thanks to a ferrocenyl redox antenna that distinguishes them from their purely organic relatives. A 60- to 150-fold increase in efficacy has been shown in their IC50 values on MDA-MB-231 cells, while healthy cells are not affected at the concentrations used. The [ferrocene-alkene spacer-paraphenol] motif appears to be essential for the compounds to become effective. These species do not operate via an alkylation of DNA, unlike ds-platin and its relatives. Several considerations militate in favor of a novel biological mechanism. These include the production... 

Thermal [2-1-2] cycloaddihon with the elechon-rich tetraferrocenyl]5]-cumulene 314 leads to a mixture of two products (Scheme 4.62), which are green and air stable ]352, 353]. Shorter cumulenes bearing up to four double bonds do not react in a ]2-i-2]-mode but form clafhrates with Cgg. Cyclovoltammetric experiments revealed complex interachons among the three redox-achve components (ferrocenyl, cumulene and fuUerene). 

The reactions of lithioferrocenes with the ruthenium cmnplexes CpRu(CO)2Cl, Cp Ru(CO)2Cl and (C6Me6)Ru(CO)Cl2 have been used to prepare the tqiproixiate metathesis products. The redox behaviour of cis-[Pt (3-ferrocenylpyridine)2Cl2] has been examined and compared with similar results previously reported for 4-ferrocenylpyiidine complexes. Ferrocene reacts with methylundecanoate to give 70% of the ferrocenyl ester in the presence of AICI3. ... 

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