Ferrocenyl bisphosphine ligand

The hydrogenation step is catalysed by an iridium(I) complex containing the chiral ferrocenyl bisphosphine ligand shown below. The ligand coordinates to the Ir(I) centre through the two P-donor atoms, and the complete catalyst... 

Mezzetti91 and Leeuwen/Widhal92 have independently reported P-chiral ferrocenyl bisphosphines 42 and 43. These two ligands have shown excellent enantioselectivity (up to 99% ee) for the asymmetric hydrogenation of... 

A series of uniquely shaped chiral ferrocenyl-based bisphosphines are available from Solvias. These ligand families (Figure 12.6) exploit a highly unsymmetric environment on the ferrocenyl backbone (see also Chapter 15). 

Close attention has been devoted in recent years to the homogeneous catalytic reduction of N-acylaminoacrylic acids with the aid of chiral Rh-complexes. In some cases exceptionally high optical yields have been achieved in these reactions. Phosphine-Rh catalysts of the DIOP type, i. e. with chiral carbon skeleton, have been used 108, 109, 133,142,145, 146, 172, 193, 194, 234), as have catalysts with phosphine oxide ligands 409), ferrocenyl-phosphine-Rh complexes 171), bisphosphine-Rh complexes with a chiral pyrrolidine ring 3, 4), systems with chiral phosphines 216—221) and bisphosphines (222), or with a chiral P- and C-skeleton 130). 

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