FERM domain

The current understanding on activation of Tec kinases fits into a two-step model. In the first step an intramolecular interaction between the SH3 domain and aproline-rich region in the TH domain is disrupted by binding ofthe PH domain to phosphoinositides, G protein subunits, or the FERM domain of Fak. These interactions lead to conformational changes of Tec and translocation to the cytoplasmic membrane where, in a second step, Src kinases phosphorylate a conserved tyrosine residue in the catalytic domain thereby increasing Tec kinase activity. Autophosphorylation of a tyrosine residue in the SH3 domain further prevents the inhibitory intramolecular interaction resulting in a robust Tec kinase activation. 

Hamada, K., Shimizu, T., Matsui, T., Tsukita, S., and Hakoshima, T., Structural basis of the membranetargeting and unmasking mechanisms of the radixin FERM domain, Embo J., 2000, 19, 4449. 

FERM FERM-domain (four-point-one ezrin, radixin, moesin)... 

Carver LA, Schnitzer JE (2003) Caveolae mining little caves for new cancer targets. Nat Rev Cancer 3 571-581 Ceccarelli DF, Song HK, Poy F et al (2006) Crystal structure of the FERM domain of focal adhesion kinase. J Biol Chem 281 252-259... 

FERM 4.1/ezrin/radixin/moesin domain Binding to cytoplasmic regions of transmembrane proteins... 

C2, protein kinase C domain ENTH, epsin N-terminal homology FERM, band 4.1,exrin, radixin, moesin FYVE, Fabl, YOTB, Vacl, EEA1 MARCKS, myristoylated alanine-rich protein kinase C substrate PH, pleckstrin homology. 

Cohen LA, Guan JL. Residues within the first subdomain of the 63. FERM-like domain in focal adhesion kinase are important in its regulation. J. Biol. Chem. 2005 280 8197-8207. 

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