Fenticonazole

Molecular formula C24H20CI2N2OS Molecular weight 455.41 CAS Registry No 72479-26-6 Merck Index 13,4033 

Sample preparation Vortex 50 (xL plasma with 100 xL 2 ng/mL IS in MeCN, centrifuge at 12 000 rpm for 2 min, inject a 20 xL aliquot of the supernatant. 

Guard column 15 x 3.2 Brownlee CIS Column 50 x 4.6 3 xm Shandon BDS C8 Column temperature 45 

Mobile phase MeCNibufifer 70 30 (The buffer was 10 mM ammonium formate adjusted to pH 3.5 with formic acid.) 

Detector MS, PE Sciex API-III-l- triple quadrupole, APCI, positive ion, heated nebulizer interface, nebulizer probe 500°, nebulizer gas nitrogen 0.6 L/min, curtain gas nitrogen at 0.8 L/min, auxiliary gas nitrogen 2.0 L/min, nebulizer gas pressure 70 psi, m/z 455—199 

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Because of their limited, activity, small spectmm, and side effects, the older topical antimycotics have generally been surpassed by newer antimycotic chemotherapeutic agents. These newer antimycotics for topical use iaclude the imida2ole derivatives clotrimazole, miconazole, econazole, isoconazole, sulconazole, fenticonazole, oxiconazole, bifonazole, butoconazole, ziaoconazole, tioconazole, and the triazole derivative, terconazole (Table 2) (5—7). The iatroduction of the azole derivatives represents a milestone ia the treatment of mycoses. 

Fenticonazole (106), on the other hand, is used topically to combat a wide variety of dermatophytes and yeasts, particularly Candida albicans. It can be synthesized from 2,4-dichlo-rophenacyl chloride (104) by reduction with borohydride and subsequent displacement with imidazole to give 105. This last undergoes ether formation with p-thiolphenylbenzyl chloride mediated by NaH to produce fcnticonazole (106) [37]. 

Enilconazole (107) has been marketed for antifungal use in plants and animals. It can be synthesized in a variety of ways including one closely analogous lo that used for fenticonazole except that the alkylating group is allyl chloride 1391,... 

Fenticonazole Isoconazole Miconazole Sertaconazole Sulconazole Tioconazole... 

C3H4N2 288-32-4) see Bifonazole Butoconazole Clotrimazole Eprosartan Fenticonazole Isoconazole Ketoconazole Miconazole Neticonazole hydrochloride Omoconazole nitrate Oxiconazole Ozagrel 1/f-imidazole lithium salt (C,H3LiN2 55986-39-5) see Flutrimazole 2-imidazolidinone... 

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