Fenfluramine improvement

Fenfluramine augmentation of SRIs in one open study benefited six of seven patients (233). Many patients have both Tourette s and OCD symptoms, and one case study found that pimozide helped Tourette s symptoms, whereas fluvoxamine helped the OCD symptoms, suggesting some specificity for each symptom (234). In a naturalistic study of Tourette s with associated OCD, adjunctive fluoxetine produced 81% improvement in the complicating OCD symptoms (235). 

Benfluorex, which is structurally related to fenfluramine, has been available since 1976 and has been used, mainfy in Erance, as an appetite suppressant [26 ] and to improve glycemic control and reduce insulin resistance in people with poorly controlled type 2 diabetes [27, 28, 29, 30, 31 ], including those with obesity [32 ",33, 34 ]. However, in 2009 the European Medicines Agency recommended the withdrawal of all medicines containing benfluorex in the European Union, because of the risks of cardiac valve disease (fenfluramine-like cardiovascular adverse effects) [35 J. 

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