Ramipril Felodipine

In the first edition of this book, I wrote of response surface designs as applied in clinical research that the field is still in its infancy . In the second edition I am tempted to report, flippantly, that the infant in question does not seem to have grown much. However, an interesting paper that reports an actual clinical trial is that by Tangen and Koch (2001). They consider an example of a 3 x 4 factorial trial in hypertension in which on average 43 patients were randomized to each of 12 possible combinations of three levels of hydrochlorothiazide (placebo, low, high) and four levels of an ACE inhibitor. (For a remarkably similar trial reported in the medical literature, see the 3x4 factorial trial of felodipine and ramipril in 507 patients reported by Scholze et al. (1999).)... 

Scholze J, Bauer B, Massaro J (1999) Antihypertensive profiles with ascending dose combinations of ramipril and felodipine ER. Clinical and Experimental Hypertension 21 1447-1462. 

No pharmacokinetic interaction occurred between single doses of fe-lodipine 10 mg and ramipril 5 mg in healthy subjects. The blood pressure-lowering effect of the eombination was greater, and ramipril attenuated the reflex taehyeardia eaused by felodipine. ... 

Bainbri e AD, MacFadyen RJ, Lees KR, Reid JL. A study of the acute phaimacodynam ic interaction of ramipril and felodipine in normotensive subjects. BrJ Clin Pharmacol ( 99 ) 31,148-53. 

Amlodipine, benazepril, captopril, enalapril, felodipine, fosinopril, lisinopril, moexipril, perindopril, quinapril, ramipril, losartan... 

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