Fatty Acids in Coagulation and Thrombosis

The in vitro and in vivo effects of salts (sodium or potassium) of various fatty acids have been investigated by Gonnor and associates (summarized by Gonnor et al., 1965). The in vitro work was carried out by injecting the blood (after 1 minute of incubation with test substance) into plastic tubing which was subsequently placed on a rotating wheel in the form of a loop. After recalcification, the time taken for solidification of the column of blood was termed the throm- 

A further complicating problem is the direct effect of fatty adds on platelets. Haslam (1964) showed that the addition of long-chain 

We are therefore left with tempting clinical speculations for which concrete evidence is totally lacking. 

---