Fatty acid synthase suppression

Pizer, E. S., Chrest, F. J., DiGiuseppe, J. A. and Han, W. F., Pharmacological inhibitors of mammalian fatty acid synthase suppress DNA replication and induce apoptosis in tumor cell lines. Cancer Res 58 (1998a) 4611-4615. 

Menendez, J.A., Ropero, S., Mehmi, I., Atlas, E., Colomer, R., and Lupu, R., Overexpression and hyperactivity of breast cancer-associated fatty acid synthase (oncogenic antigen-519) is insensitive to normal arachidonic fatty acid-induced suppression in lipogenic tissues but it is selectively inhibited by tumoricidal alpha-linolenic and gamma-lrnolenic fatty acids a novel mechanism by which dietary fat can alter mammary tumorigenesis, Int. J. Oncol., 24, 1369, 2004. 

This is a similar approach to that described above. Use of a yeast strain deficient in fatty acid synthase (FAS) suppressed formation of the undesired trans-diastereomer of a p-lactam as shown in Fig. 15-22[129 . 

The key enzyme for lipogenesis fatty acid synthase (FAS) has been shown to be significantly suppressed by tea extracts and tea polyphenols, including EGCG and TF-3 in human breast carcinoma cells expression of FAS was enhanced by EGF and inhibited by the presence of tea polyphenols. These experimental data indicate that suppression of FAS may result from downregulation of the EGF receptor/PI3K/Akt signal transduction pathway (unpublished results). 

SUPPRESSION OF FATTY ACID SYNTHASE BY TEA POLYPHENOLS IN VIVO... 

Ren, B., Thelen, A. P., Peters, J. M., Gonzalez, F. J., and Jump, D. B. Polyunsaturated fatty acid suppression of hepatic fatty acid synthase and S14 gene expression does not require peroxisome proliferator-activated receptor alpha. J Biol Chem 272 (1997) 26827-26832. 

Teran-Garcia, M., Adamson, A. W., Yu, G., Rufo, C., Suchankova, G., Dreesen, T. D., Tekle, M., Clarke, S. D. and Gettys, T. W., Polyunsaturated fatty acid suppression of fatty acid synthase (FASN) evidence for dietary modulation of NF-Y binding to the Fasn promoter by SREBP-lc, Biochem /402 (2007) 591-600. 

L. Suppression of Fatty Acid Synthase through Downregulating EGFR and the PI3k-AKt Signal Transduction Pathway... 

Fatty acid transport proteins The mitochondrial and peroxisomal enzymes of fatty acid oxidation Carnitine palmitoyl transferase I HMG-CoA synthase Apoprotein Clll (suppression)... 

Wang, Z., and Tai, H.H. (1999) Cyclic AMP Response Element Mediates Dexamethasone Induced Suppression of Prostaglandin H Synthase-2 Gene Expression in Human Amnion Derived WISH Cells, Prostaglandins Leukot. Essent. Fatty Acids 60,243-238. 

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