Fasting glucose essential

Snoke and Nordlie (82, 83) have extended these studies of Duttera et al. (87) to include PPS-glucose phosphotransferase as well as glucose-6-P phosphohydrolase activity of the enzyme and have also noted essentially parallel progressive losses of both activities concomitant with release of acid-soluble phosphate resulting from phospholipase C action. A partial (fed animals) or total (fasted rats) restoration of both activities was effected by phospholipid supplementation of phospholipase-treated preparations. However, as indicated by detailed studies of catalytic properties of the various preparations, the enzyme was not restored to its... 

In 424 patients in a European multicenter, randomized, double-blind study for 1 year, two-thirds of the patients used repaglinide (0.5—4 mg tds) and the others glibencla-mide (1.75-10.5 mg/day) (19). I IbAlc first fell but later increased. The same trends were seen in fasting blood glucose. There were no differences in hypoglycemia. A comparable American study of 576 patients (20) showed essentially the same result. 

When food intake decreases, the utilization of fat and protein reserves in the body enables various essential metabolic processes to continue during the nutritional inadequacy. In the early stage of fasting or starvation, glucose requirements of the brain and nervous system are fulfilled by mobilization of glycogen in the liver. This short-term adaptation lasts only a day until glycogen stores are exhausted. Gluconeogenesis... 

During exercise, blood glucose is maintained by essentially the same mechanisms that are used during fasting. 

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