Famotidine polymorphs

W.-T. Cheng, S.-Y. Lin and M.-J. Li, Raman microspectroscopic mapping or thermal system used to investigate milling-induced solid-state conversion of famotidine polymorphs, J. Raman Spectrosc., 38, 1595-1601... 

FIGURE 6 X-ray powder diffraction patterns for famotidine polymorphic form-A (solid trace) and polymorphic form-B (dashed trace) (H. G. Brittain, unpublished results). 

A 41-year-old woman, with liver lacerations, rib fractures, and pneumothorax after a motor vehicle accident, was given haloperidol for agitation on day 7. During the first 24 hours she received a cumulative intravenous dose of 15 mg, 70 mg on day 2, 190 mg on day 3,160 mg on days 4 and 5, and 320 mg on day 6. An hour after the first dose of 80 mg on day 7, she had ventricular extra beats followed by 5-beat and 22-beat runs of ventricular tachycardia. The rhythm strips were consistent with polymorphous ventricular tachycardia or torsade de pointes and the QTC interval was 610 ms (normally under 450 in women). She received intravenous magnesium sulfate 2 g. Concurrent medications included enoxaparin, famotidine, magnesium hydroxide, ampicillin/sulbactam, nystatin suspension, midazolam, and 0.45% saline with 20 mmol/1 of potassium chloride. She had no further dysrhythmias after haloperidol was withdrawn. Eight days after the episode of torsade de pointes she had a QTC interval of 426 ms. 

Cheng, W.T. Lin, S.Y. Wang, S.L. (2008). Differential Scanning Calorimetry with Curve-Fitting Program Used to Quantitatively Analyze the Polymorphic Transformation of Famotidine in the Compressed Compact. Drug Development and Industrial Pharmacy, Vol 34, No. 12, (December 2008), pp. 1368-1375, ISSN 0363-9045... 

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