Itraconazole Famotidine

Famotidine-OTC antacids and antifungal drugs (ketoconazole, itraconazole)... 

Famotidine 40 mg/kg/day reduced the peak and trough concentrations of itraconazole 200 mg/kg/day by about 35% in 18 patients undergoing chemotherapy for hematological malignancies (86). 

Kanda Y, Kami M, Matsuyama T, Mitani K, Chiba S, Yazaki Y, Hirai H. Plasma concentration of itraconazole in patients receiving chemotherapy for hematological malignancies the effect of famotidine on the absorption of itraconazole. Hematol Oncol 1998 16(l) 33-7. 

Drug interactions Cimetidine is a CYP450 inhibitor and can inhibit the metabolism of phenytoin, warfarin, and theophylline. Famotidine, nizatidine, and ranitidine are unlikely to cause clinically significant drug interactions. All antagonists have the potential to interact with other drugs that require gastric acid for absorption (e.g., ketoconazole, itraconazole). 

Famotidine 40 mg was found to reduce the serum levels of a 200-mg dose of itraconazole by about 50% in 12 healthy subjects. Famotidine 20 mg twice daily was given with itraconazole 200 mg daily for 10 days to 16 patients undergoing chemotherapy for haematological malignancies. The minimum plasma levels of itraconazole were reduced by about 39%, and 8 patients did not achieve the levels considered necessary to protect neutropenic patients from fungal infections. ... 

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See also in sourсe #XX -- [ ]

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