Faecalibacterium prausnitzii

Sokol, H., Seksik, R, Euret, J. R, Eirmesse, O., Nion-Larmurier, I., Beaugerie, L., et al. (2009). Low counts of Faecalibacterium prausnitzii in colitis microbiota. Inflammatory Bowel Diseases, 15, 1183-1189. 

Inulin qPCR 10 g/day, 16 days, 12 healthy adults Treatment compared to no treatment period Bifidobacteria Faecalibacterium prausnitzii Ramirez-Farias et al. ... 

The final criterion for a prebiotic is that its fermentation in the colon has some beneficial impact on host health. In vitro studies using models of the colonic microbiota inoculated with human feces and studies in animals, have shown that fermentation of prebiotic fructans leads to accumulation of acetate and butyrate in intestinal/gut model contents. Fermentation of other prebiotics and certain dietary fibers has also been shown to increase propionate production in these systems. Small amounts of lactate and succinate can also be observed using in vitro models, but in vivo, these SCFA are rapidly converted into butyrate and propionate by the gut microbiota. Bifidobacteria and lactobacilli ferment carbohydrates mainly to acetate and lactate, but do not themselves produce butyrate. Recent studies have shown that dominant members of the Firmicutes, Eubacterium halli, Roseburia, Faecalibacterium prausnitzii and Anaerostipes caccae are able to cross-feed off acetate and lactate within the colonic milieu converting them into butyrate, providing a mechanism by which prebiotic modulation of acetate-produdng bifidobacteria can lead to elevated butyrate concentrations within the SCFA have been implicated... 

Sokol H, Seksik P, Furet JP, et al. Low counts of Faecalibacterium prausnitzii in colitis microbiota. Inflamm Bowel Dis. 2009 15 1183—1189. 

Ramirez-Farias C, Slezak K, Fuller Z, Duncan A, Holtrop G, Louis P. Effect of inulin on the human gut microbiota stimulation of Bifidobacterium adolescentis and Faecalibacterium prausnitzii. Br ] Nutr. 2009 101 541-550. 

Lopez-Siles M, Khan TM, Duncan SH, Harmsen HJM, Garcia-Gil LJ, Flint HJ. Cultured representatives of two major phylogroups of human colonic faecalibacterium prausnitzii can utilize pectin, uronic acids, and host-derived substrates for growth. Appl Environ... 

Sokol H, Pigneur B, Watterlot L, et al. Faecalibacterium prausnitzii is an anti-inflammatory commensal bacterium identified by gut microbiota analysis of Crohn disease patients. Proc Natl Acad Sci USA. 2008 105(43) 16731—16736. 

In the GI tract, prebiotics selectively stimulate indigenous beneficial bacteria such as bifidobacteria and lactobacilli (Reid etal. 2003b). However, recent studies show that other gut commensals, such as Faecalibacterium prausnitzii, also have the ability to degrade these compounds, producing butyrate as an end-product of fermentation (Ramirez-Farias et al. 2008). Products of prebiotic fermentation by lactobacilli and bifidobacteria, such as lactic and acetic acid, can also be subsequently degraded by other members of the gut (Duncan et al. 2004 Duncan, Louis, and Flint 2004 Falony etal. 2006). Although the... 

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