Factors Influencing the Water Solubilities of Crystalline Drugs

Artificial neural network Multiple linear regression (Statistica) 

Overall H-bond acidity (Absolv) also as Saj1 [8] 

Product of overall H-bond acidity and basicity (Absolv) Molecular polarizability in A3 (HYBOT) [23] also Alpha Overall H-bond basicity (Absolv) also as Sp 1 [8] 

Largest H-bond acceptor value in molecule (HYBOT) [23] also Ca max 

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McFarland, J. W. Du, C. M. Avdeef, A., Factors influencing the water solubility of crystalline drugs, in van de Waterbeemd, H. Lennemas, H. Artursson, P. (eds.), Drug Bioavailability. Estimation of Solubility, Permeability, Absorption and Bioavailability, Wiley-VCH, Weinheim, 2003 (in press). 

Factors Influencing the Water Solubilities of Crystalline Drugs... 

McFarland JW, Du CM, Avdeef A. Factors Influencing the water solubilities of crystalline drugs. Methods and Principles in Medicinal Chemistry 2003 55 1 163-1 183,... 

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