Factors influencing solvent hepatotoxicity

The lipid solubihty of solvents also favors their deposition of into lipid rich organ systems such as the fiver. The toxicity of a particxdar solvent may be enhanced by its long residence time in the liver.  

2 Microscopic, Biochemical and Clinical Findings Associated with Liver Injury due to Solvents 

Current research focuses on the effect of low doses of solvents on the liver, with concern that low grade prolonged solvent expostu e cotdd lead to chronic injury and eventual impairment.  

Clearance tests of liver fimction assess a number of physiologic activities including hepatic uptake, hepatic metabolism, and hepatic excretion. Typical clearance tests of liver function include indocyanine green (ICG), antipyrine clearance test and C aminopyrine breath test. These tests give an estimation of the ability of the liver to extract and detoxify exogenous toxins (xenobiotics). Measuring the excretion of endogenously produced serum bile acids is an additional measure of hepatic clearance and has been used as a sensitive measure of early solvent hepatotoxicity. 

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